Lady saw her mother brutally sacrificed by her father Arkham, a librarian who became obsessed with the demonic and the nature of evil, as part of a ritual that was meant to make him a demon. She abandoned her true name, Mary, since it was given to her by her father, and embarked on a quest for revenge, despising all demons. Driven by her hate and a desperate need for vengeance, she was initially at odds with Dante, who she saw as nothing more than a demon himself, but eventually she came to realize he was much more than that, after seeing him shed a tear over the loss of his brother. By the end of DMC3, Lady had her revenge, and she and Dante parted ways. She even adopted the name "Lady", which Dante had taken to calling her offhand after she told him she had no name. Lady is older in the film and has, for the most part, put most of her psychosis behind her, although she maintains her deep hatred for the demonic. Just like she promised Dante in DMC3, she became a demon hunter, and has spent over 10 years since then battling demons wherever she finds them. The events of TTOS lead to her teaming up with Dante to combat a new enemy.

Played by: Rachel Lund

Rachel is a professional dancer, and a Drama and Dance University graduate. She is the only member of the cast who hadn't played DMC when she joined the project, but James has had her watching through the games cutscenes, Dream has provided plenty of material for her to work from, and she has quickly come to love the character and series.